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KMID : 0882420090760060682
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Korean Journal of Medicine
2009 Volume.76 No. 6 p.682 ~ p.684
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Implication of aspirin resistance: Simple laboratory finding or important clinical criteria?
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Jeong Young-Hoon
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Abstract
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Aspirin resistance defined by light transmittance aggregometry (LTA) or urinary 11-dehydro-thromboxane B2 has been associated with an increased risk of adverse clinical events. However, aspirin resistance based on the point-of-care VerifyNow-Aspirin assay (aspirin reaction unit ≥550) shows poor sensitivity compared with LTA. In aspirin-treated patients, activation by cyclooxygenase?independent pathways may be associated with residual platelet reactivity, which may cause adverse clinical outcomes in some portion. A large-scale, prospective study using several platelet function assays should be performed to establish the long-term clinical significance of antiplatelet resistance in Korean patients treated with coronary stenting. Accordingly, we can apply tailored antiplatelet therapy in resistant patients.
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KEYWORD
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Aspirin resistance, VerifyNow-Aspirin, Tailored antiplatelet therapy
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